Radioactive iodine compound for labeling an antibody

Details Radioactive iodine compound for labeling an antibody Radioactive iodine compound for labeling an antibody

1991-12-02

1993-10-12

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5303915, 530405, C07D207448, C07K 308, C12Q 166, C12N 996

Patent

active

052527484

ABSTRACT:
The radioactive iodine compound of this invention or an intermediate for preparing the compound is represented by the following formula (I): ##STR1## wherein R is H or .sup.125 I. The radioactive compound can readily introduce a radioactive isotope element such as .sup.125 I into an antibody molecule without damaging the activity of the antibody molecule. Therefore, the compound can preferably be used to label an antibody of immunoradiometric assay, and allow a higher degree of measurement sensitivity.

REFERENCES:
patent: 4214098 (1980-07-01), Kitagawa et al.
patent: 4980457 (1990-12-01), Jansen et al.
P. C. Srivastava et al., J. Nuclear Med. (1990) 31(5):906.

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