Racemic separation of 2,6-trans-dimethymorpholine

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

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C544S107000

Reexamination Certificate

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07829702

ABSTRACT:
A process for preparing optically active trans-2,6-dimethylmorpholine by (i) reacting racemic trans-2,6-dimethylmorpholine with D-mandelic acid, (ii) removing the salt formed from D-mandelic acid and one enantiomer of trans-2,6-dimethylmorpholine from the other enantiomer of trans-2,6-dimethylmorpholine and (iii) isolating the desired optically active trans-2,6-dimethylmorpholine.

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Wilen, S. H., et al., “Strategies in Opitical Resolutions”, Tetrahedron, 1977, vol. 33, pp. 2725-2736.
Licandro, E., et al., “Enantioselective Synthesis of (R)-(—)-Baclofen using Fischer-type Carbene Anions”, Tetrahedron: Asymmetry, 2000, vol. 11, pp. 975-980.
Licandro, E., et al., “Improved Synthesis of (—)-(2R,6R)-2,6-Dimethylmorpholine”, Gazzetta Chimica Italiana, 1997, vol. 127, pp. 815-817.

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