Rabconnectin-3-binding protein

Details Rabconnectin-3-binding protein Rabconnectin-3-binding protein

2007-10-09

2007-10-09

Carlson, Karen Cochrane (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

11483356

ABSTRACT:
A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an anti-Rab3A GEP antibody, a protein participated in the regulation of activation or inactivation of Rab3A is determined. As the protein binds to rabconnectin-3 and GDP/GTP exchange protein, it can be used for screening for a material that increases or decreases the binding.

REFERENCES:
patent: 2002/0040484 (2002-04-01), Roch et al.
patent: 0 856 583 (1998-08-01), None
patent: 10-276783 (1998-10-01), None
patent: 2001-309733 (2001-11-01), None
patent: WO01/66739 (2001-09-01), None
Wang et al., Rim1 and Rabphilin-3 Bind Rab3-GTP by Composite Determinants Partially related through N-terminal alpha-helix Motifs, Journal of Biological Chemistry, vol. 276, No. 35, (2001), p. 32480-32488.
Nagano, et al., “Molecular Cloning and Characterization of the Noncatalytic Subunit of the Rab3 Subfamily-Specific GTPase-Activating Protein”,The Journal of Biological Chemistry, 273(38): 24781-74785, 1998.
Nagano, et al., “Rabconnectin-3, a Novel Protein that Binds Both GDP/GTP Exchange Protein and GTPase-Activating Protein for Rab3 Small G Protein Family”,The Journal of Biological Chemistry, 277(12): 9629-9632, 2002.
Nakanishi, et al., “Isolation of Regulatory Proteins for the Rab3 Subfamily GTPases”,Methods in Molecular Biology, 189: 143-157.
Oishi, et al., “Localization of the Rab3 Small G Protein Regulators in Nerve Terminals and Their Involvement in Ca2+—Dependent Exocytosis”,The Journal of Biological Chemistry, 273(51): 34580-34585, 1998.
Sanders, et al., “Assignment of WDR7 (Alias TRAG, TGF-β Resistance Associated Gene) to Orthologous Regions of Human Chromosome 18q21.1→q22 and Mouse Chromosome 18D.1-E.3 by Fluorescence in Situ Hybridization”,Cytogenet Cell Genet, 88: 324-325, 2000.
Tanaka, et al., “Role of Rab3 GDP/GTP Exchange Protein in Synaptic Vesicle Trafficking at the Mouse Neuromuscular Junction”,Molecular Biology of the Cell, 12: 1421-1430, 2001.
Wada, et al., “Isolation and Characterization of A GDP/GTP Exchange Protein Specific for the Rab3 Subfamily Small G Proteins”,The Journal of Biological Chemistry, 272(7): 3875-3878, 1997.
Yamaguchi, et al., “A GDP/GTP Exchange Protein for the Rab3 Small G Protein Family Up-Regulates a Postdocking Step of Synaptic Exocytosis in Central Synapes”,PNAS, 99(22): 14536-14541, 2002.

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