(R)-2-hydroxy-3-phenylpropionate (d-phenyllactate)...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

Reexamination Certificate

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Details

C435S004000, C435S006120, C435S069100, C435S071100, C435S252300, C435S320100, C435S026000, C536S023200

Reexamination Certificate

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06916641

ABSTRACT:
An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid dehydrogenase. A D-phenyllactic acid dehydrogenase according to the present invention is a protein comprising an amino acid sequence of the amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that has one or more modifications selected from a substitution, a deletion, an addition and an insertion and has D-phenyllactic acid dehydrogenase activity. A D-phenyllactic acid dehydrogenase gene according to the present invention comprises a nucleotide sequence which encodes the D-phenyllactic acid dehydrogenase, for example the nucleotide sequence of SEQ ID NO: 1.

REFERENCES:
patent: 97/20945 (1997-06-01), None
patent: 01/18179 (2001-03-01), None
patent: 01/18219 (2001-03-01), None
Chistoserdova et al. NCBI—Accession Q59516, 1997.
Wilks et al. Biochemistry. Sep. 1, 1992;31(34):7802-6.
Hayao Taguchi et al., “D-Lactate Dehydrogenase Is a Member of the D-Isomer-specific 2-Hydroxyacid Dehydrogenase Family”, The Journal of Biological Chemistry, vol. 266, No. 19, pp. 12588-12594, Jul. 5, 1991.
Wolfram Weckwerth et al., “Biosynthesis of PF1022A and Related Cyclooctadepsipeptides”, The Journal of Biological Chemistry, vol. 275, No. 23, pp. 17909-17915, Jun. 9, 2000.

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