Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-06-19
2007-06-19
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S323000, C546S200000, C546S236000
Reexamination Certificate
active
10659164
ABSTRACT:
Quinolylpropylpiperidine derivatives of general formula (I) in which R1is hydrogen or fluorine, R2is carboxyl, carboxymethyl or hydroxymethyl, R3is alkyl substituted either with phenylthio optionally substituted with halogen, hydroxyl, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkyloxycarbonyl, cyano or amino, or with cycloalkylthio (3 to 7 members) optionally substituted with halogen or trifluoromethyl, or with heteroarylthio (5 to 6 members and 1 to 4 heteroatoms chosen from N, O and S), optionally substituted with halogen, hydroxyl, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkyloxycarbonyl, cyano or amino or R3is propargyl substituted by phenyl or heteroaryl as defined above and R4is alkyl, alkenyl-CH2— or alkynyl-CH2—, cycloalkyl or cycloalkylalkyl, in their various isomeric forms, separate or as mixtures, and also their salts, their preparation process and intermediates and the compositions containing them. These novel derivatives are potent antibacterial agents
REFERENCES:
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Grethe, Guenter et al, “Reinvestigation of the Classical Synthesis of Cinchona Alkaloids. I. A New Synthesis of Homomeroquinene and Quinotoxine,” Helvetica Chimica Acta, vol. 56(5), 1973, pp. 1485-1494.
G. Grethe, et al., “107.Synthesis of 9-epi-Quinine and 9-epi-Quinidine,” Helvetica Chimica Acta, 55 Fasc. 3 (1972) No. 107, pp. 1044-1047.
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Ahmad Youssef El
Bacque Eric
Bigot Antony
Malleron Jean-Luc
Mignani Serge
Coppins Janet L.
Harness & Dickey & Pierce P.L.C.
Novexel SA
Saeed Kamal A.
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