Quinolizinone type compounds

Details Quinolizinone type compounds Quinolizinone type compounds

1994-09-30

1996-12-03

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142305, 514250, 514252, 514253, 514258, 514278, 514300, 514303, 514306, 544 71, 544230, 544280, 544105, 544350, 544364, 544284, 544285, 544286, 544287, 544289, 546 15, 546113, 546138, A61K 31495, A61K 31505, C07D40100, C07D23972

Patent

active

055808727

ABSTRACT:
Antibacterial compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those compounds wherein
A is .dbd.CR.sup.6 --;
R.sup.1 is cycloalkyl of from three to eight carbon atoms or substituted phenyl;
R.sup.2 is selected from the group consisting of ##STR2## R.sup.3 is halogen; R.sup.4 is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group;
R.sup.5 is hydrogen, loweralkyl, halo(loweralkyl), or --NR.sup.13 R.sup.14 ; and
R.sup.6 is halogen, loweralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy, or amino(loweralkyl),
as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

REFERENCES:
patent: 4495189 (1985-01-01), M esz aros et al.
patent: 4861779 (1989-08-01), Jefson et al.
patent: 5158951 (1992-10-01), Hermecz et al.
patent: 5387588 (1995-02-01), Hermecz et al.

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