Quinolinyl guanidines having antiinflammatory, analgesic or anti

Details Quinolinyl guanidines having antiinflammatory, analgesic or anti Quinolinyl guanidines having antiinflammatory, analgesic or anti

1978-10-27

1981-10-06

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424856, 424250, 424251, 424258, 544 63, 544 64, 544181, 544212, 544225, 544322, 544405, 546 9, 546 10, 546153, 546157, 546163, A61K 3147, A61K 31555, C07D21542

Patent

active

042935490

ABSTRACT:
This invention relates to new compounds, salts, complexes and acylated derivatives thereof, methods of producing said compounds, intermediates used in the method, pharmaceutical compositions containing the present compounds and methods of producing same, and a method of treating patients using the present compounds, having the general formula (I) ##STR1## in which R.sub.1 represents hydrogen, alkyl, alkoxy, hydroxy, halogen, trifluoromethyl, or phenyl; R.sub.2 represents hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, or hydroxy; R.sub.3 represents alkyl, cycloalkyl which can be further mono- or disubstituted with methyl or ethyl, phenyl or phenyl-alkyl, optionally being further substituted; and R.sub.4 represents a 5- or 6-membered heterocyclic ring system containing at least one nitrogen atom and optionally further nitrogen, oxygen and/or sulphur atoms, said ring system optionally being further substituted; or said ring system optionally forming part of a larger fused ring system; and pharmaceutically acceptable, non-toxic salts, complexes and acylated derivatives thereof. The present compounds can be used in the therapy of rheumatoid arthritis, osteo-arthritis, and allied conditions in humans and domestic animals by enteral, parenteral or topical administration.

REFERENCES:
patent: 3056789 (1962-10-01), Urech
patent: 3159676 (1964-12-01), Geoffrey et al.
patent: 4000279 (1976-12-01), Hughes et al.
The Merck Index, 9th ed., Merck & Co., Rahway, N.J. (1976) p. 276.
Durant, et al., J. Med. Chem., vol. 9, pp. 22-27, (1966).
Kishore, et al., Pharmacology, vol. 15, pp. 97-103 (1977).
Raman, et al., Derwent Abstract 35984T (1978).
Lombardino, et al., J. Med. Chem., vol. 16, No. 5, pp. 493-496 (1973).
Wiseman, et al., Biochemical Pharmacology, vol. 21, pp. 2323-2334 (1972).

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