Quinolinones and uses thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C546S153000, C546S155000, C546S157000, C546S158000

Reexamination Certificate

active

07019139

ABSTRACT:
The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof):in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q, r and X are as defined herein, and to their preparation and use.

REFERENCES:
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patent: 6150377 (2000-11-01), Lyssikatos et al.
patent: 6169096 (2001-01-01), Venet et al.
patent: 6713462 (2004-03-01), Metcalf et al.
patent: WO 97/21701 (1997-06-01), None
patent: WO 98/55124 (1998-12-01), None
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patent: WO 00/01411 (2000-01-01), None
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patent: WO 00/12499 (2000-03-01), None
patent: WO 02/24682 (2002-03-01), None
patent: WO 02/24683 (2002-03-01), None
patent: WO 02/24686 (2002-03-01), None
patent: WO 02/24687 (2002-03-01), None
Boschelli, D.H. Et al. Synthesis and Src Kinase Inhibitory Activity of a Series of 4-phenylamino-3-quinolinecarbonitriles. J. Med.Chem. Jan. 2001, vol. 44, pp. 822-833.
Database CA on STN, Chemical Abstracts, (Columbus, OH, USA), No. 134:100834, Wang, Y.D. “Inhibitors of Src tyrosine kinase: the preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines,” abstract, Bioorganic & Medicinal Chemistry Letters, 2000, vol. 10, No. 21, pp. 2477-2480.
Database CA on STN, Chemical Abstracts, (Columbus, OH, USA), No. 129:302564, Wissner, A. “Preparation of substituted 3-cyanoquinolines as inhibitors of protein tyrosine kinase,” abstract WO9843960, Oct. 1998, p. 223.

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