Quinoline or quinazoline derivatives inhibiting...

Details Quinoline or quinazoline derivatives inhibiting... Quinoline or quinazoline derivatives inhibiting...

2002-10-17

2009-02-24

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S163000, C544S283000, C514S312000, C514S313000, C514S257000

Reexamination Certificate

active

07495104

ABSTRACT:
An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof:wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(═O)m, wherein m is 0 to 2, or urea; R1to R3each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4represents H; R5to R8each independently represent H, halogen, alkyl, or alkoxy; and R9represents an optionally substituted carbocyclic or heterocyclic group.

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Yanong D. Wang, et al., “Inhibitors of Src Tyrosine Kinase: the preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines”, Bioorganic & Medicinal Chemistry Letters, vol. 10, pp. 2477-2480, 2000.
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Y. Wang, et al., “Inhibitors of Src Tyrosine Kinase: The Preparation and Structure-Activity Relationship of 4-Anilino-3-cyanoquinolines and 4-Anilinoquinazolines”, Bioorganic &Medicinal Chemistry Letters, vol. 10, 2000, pp. 2477-2480.

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