Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

1988-09-16

1990-06-12

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544 80, 544333, 544363, 546167, 546169, 546170, 546171, A61K 3147, A61K 31535, C07D41304, C07D21538

Patent

active

049334476

ABSTRACT:
A quinoline derivative represented by the following formula is disclosed. ##STR1## wherein R.sub.1 represents a hydrogen atom or an alkyl group which may contain a substituent and R.sub.2 represents an alkyl group which may contain a substituent, or R.sub.1 and R.sub.2 in combination with each other and with the adjacent nitrogen atom from a ring which may contain a nitrogen atom other than said adjacent nitrogen atom, an oxygen atom, or a substituent, and R.sub.3 represents a cyano group, a carbamoyl group, or a lower alkoxycarbonyl group. The compound exhibits superior cardiotonic activity and vasodilative activity, and thus is effective as a medicine.

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Chemical Abstract, vol. 98, No. 1, Jan. 3, 1983, Columbus, Ohio, U.S.A., Kumar, V. Vijaya et al., "Formation Constants and Thermodynamic Parameters of Iron (II) Chelates with Quinoline-8-Carboxylic and Quinoxaline-2-Carboxylic Acids and their Substituted Derivatives in Aqueous Ethanol Medium".
Chemical Abstract, vol. 109, No. 11, Sep. 12, 1988, Konno Fujiko et al., "Preparation of Aminoquinoline Derivatives as Antiinflammatory Agents and Cardiotonics".
Chemical Abstract, vol. 83, No. 23, Dec. 8, 1975, Hughes, John L. et al., "Cardiovascular Activity of Aromatic Guanidine Compounds".
Chemical Abstract, vol. 105, No. 13, Sep. 29, 1986, Dionne Gervais et al., "Ligand-Receptor Interactions via Hydrogen-Bond Formation, Synthesis and Pharmacological Evaluation of Pyrrolo and Pyrido Analogs of the Cardiotonic Agent 7-Hydroxycylindole".

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