Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-04-19
2011-04-19
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S266200, C514S266220, C544S293000
Reexamination Certificate
active
07928107
ABSTRACT:
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
REFERENCES:
patent: 3340260 (1967-09-01), Morton Blatter Herbert
patent: 3637693 (1972-01-01), Otterstedt et al.
patent: 3819628 (1974-06-01), Simpson et al.
patent: 4306065 (1981-12-01), Chen
patent: 4377582 (1983-03-01), Chen
patent: 6169088 (2001-01-01), Matsuno et al.
patent: 6184226 (2001-02-01), Chakravarty et al.
patent: 6608056 (2003-08-01), Hayakawa et al.
patent: 6613772 (2003-09-01), Schindler et al.
patent: 7189733 (2007-03-01), Scarborough et al.
patent: 2002/0151544 (2002-10-01), Hayakawa et al.
patent: 2004/0248890 (2004-12-01), Gonzales et al.
patent: 2006/0154935 (2006-07-01), Wilson et al.
patent: 2006/0166963 (2006-07-01), Silva et al.
patent: 2006/0173018 (2006-08-01), Wilson et al.
patent: 2006/0217377 (2006-09-01), Gonzales et al.
patent: 2008/0167305 (2008-07-01), Wilson et al.
patent: 119051 (1965-04-01), None
patent: 2121031 (1972-11-01), None
patent: 1231211 (1995-05-01), None
patent: 1277738 (2003-01-01), None
patent: 0655456 (2010-06-01), None
patent: 2295387 (1996-05-01), None
patent: 58-172379 (1983-10-01), None
patent: 08003144 (1996-01-01), None
patent: 2000229950 (2000-08-01), None
patent: 2001-89452 (2001-04-01), None
patent: 98/14431 (1998-04-01), None
patent: 98/25895 (1998-06-01), None
patent: 99/32460 (1999-07-01), None
patent: 01/32632 (2001-05-01), None
patent: 02/14271 (2002-02-01), None
patent: 02/24667 (2002-03-01), None
patent: 03/097615 (2003-11-01), None
patent: 2004/030672 (2004-04-01), None
patent: 2004/078733 (2004-09-01), None
patent: 2006/028904 (2006-03-01), None
patent: 2007058989 (2007-05-01), None
ERB et. al., J. Het. Chemistry, vol. 37 (2000), pp. 253-260.
Gorvin, J. of Chem. Research Synopses 9, pp. 294-295 (1989).
Baig et al., J of Chem. Society, Perkin Transaction 1: Organic & Biorganic Chemistry 5, pp. 999-1003 (1984).
Partridge et al., J. of Chem. Society, Section C: Organic 19 pp. 2641-2647 (1970).
Dass et al., J. of Scientific & Industrial Research 11B, p. 461-463 (1952).
Petridou-Fischer J. et al., Journal of Heterocyclic Chemistry, vol. 20, 1983, pp. 1159-1167, XP002394184 p. 1160, left hand Column.
Berge, et al., J. Pharm. Sci., 66(1), 1977, pp. 1-19.
Jordan, V.C. Nature Reviews: Drug Discovery, 2, 2003, p. 205.
Cardellini et al., IL Farmaco Ed, Sci., vol. 30, No. 7, pp. 536-543, 1975.
Lee et al., “Discovery of Potent Cyclic GMP Phosphodiesterase Inhibitors. 2-Pyridyl-and 2- Imidazolyquinazolines Possessing Cyclic GMP Phosphodiesterase and Thromboxane Synthesis Inhibitory Activities”, J. Med. Chem., vol. 38, No. 18, pp. 3547-3557, 1995.
Suma et al., “Na and High-voltage-activated Ca2+ Channel Blocking Actions of NS-7, a Novel Neuroprotective Agent, in NG108-15 Cells”, Euro. Journal of Pharmacology vol. 336, No. 2/3, pp. 283-290, 1997.
Taylor et al., “Na Channels as Targets for Neuroprotective Drugs”, Elsevier Science Ltd., vol. 16, No. 9, pp. 309-316, 1995.
ERB et al., “Synthesis of 2-Aminoquinazoline-4(3H)-one Derivatives as Potential Potassium Channel Openers”, J. Heterocyclic Chem., vol. 37, pp. 253-260, 2000.
Gupta et al., “Drugs Acting on the Central Nervous System. Syntheses of Substituted Quinazolones and Quinazolines and Triazepino- and Triazocinoquinazolenes”, J. Chem., Am. Chem. Soc., vol. 11, No. 2 pp. 392-395, 1968.
Bodajla et al., Chem. Papers 48 (6), 432-436 (1994).
Bodajla et al., Coll. of Czech. Chem. Comm. 59(6), 1463-1466 (1994).
Dorwald, F. Zaragoza. Side Reactions In Organic Synthesis: A Guide to Successful Synthesis Design, Weinheim: WILEY-VCH Verlag Gmbh & Co. KgaA, 2005, Preface.
Fanning Lev
Gonzalez Jesus
Hurley Dennis
Joshi Pramod
Krenitsky Paul
Brennan Nancy K.
Truong Tamthom N
Vertex Pharmaceuticals Incorporated
Wilson James O
LandOfFree
Quinazolines useful as modulators of ion channels does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Quinazolines useful as modulators of ion channels, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinazolines useful as modulators of ion channels will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2697136