Quinazolines as inhibitors of endothelin converting enzyme

Details Quinazolines as inhibitors of endothelin converting enzyme Quinazolines as inhibitors of endothelin converting enzyme

1994-12-22

1997-08-19

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514259, 514254, 514255, 5142282, 514212, 544293, 544116, 544284, 544238, 544357, 544296, 544 62, 540600, 540582, C07D40112, C07D40312, C07D40512, A61K 31505

Patent

active

056589026

ABSTRACT:
Novel quinazoline inhibitors of endothelin converting enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin and in controlling hypertension, myocardial infarction and ischemia, metabolic, endocrinological, and neurological disorders, congestive heart failure, endotoxic and hemorrhagic shock, septic shock, subarachnoid hemorrhage, arrhythmias, asthma, acute and chronic renal failure, cyclosporin-A induced nephrotoxicity, angina, gastric mucosal damage, ischemic bowel disease, cancer, pulmonary hypertension, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, cerebral ischemia and vasospasm, and diabetes.

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