Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-04-15
1981-07-21
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544291, A61K 31505, C07D40304
Patent
active
042799104
ABSTRACT:
A series of novel 4-amino-6,7-di(lower alkoxy)-2-(4-substituted piperazino)quinazoline derivatives have been prepared, including their pharmaceutically acceptable acid addition salts. These derivatives all possess a benzo-oxacycloalkanoyl moiety located at the 4-position of the piperazine ring. Such compounds are useful in therapy as highly potent antihypertensive agents. 4-Amino-2-[4-(chroman-2-carbonyl)piperazino]-6,7-dimethoxyquinazoline represents a typical and preferred member compound. Methods for preparing all these compounds from known starting materials are provided and the principal synthetic route leading to the desired final products is described in some detail.
REFERENCES:
patent: 3511836 (1970-05-01), Hess
patent: 4001237 (1977-01-01), Partyka et al.
patent: 4026894 (1977-05-01), Winn et al.
Coughlan, Jr. Paul M.
Knuth Charles J.
Murphy Francis X.
Pfizer Inc.
Richardson Peter C.
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