Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1993-04-30
1998-05-19
Owens, Amelia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 91, 514109, 546 23, 548111, 562 21, A61K 31675, A61K 3166
Patent
active
057536341
ABSTRACT:
Disclosed are quaternary nitrogen-containing, saturated or unsaturated monocyclic and bicyclic ring-containing bisphosphonate compounds, and pharmaceutically-acceptable salts and esters thereof. These compounds, which are useful for treating or preventing disorders of calcium and phosphate metabolism, have the following general structure: ##STR1## wherein (a) each X and Y are independently selected from nil, O, S, NR.sup.1 and N.sup.+ (R.sup.2).sub.2 ; if no R.sup.1 is N.sup.+ (R.sup.2).sub.2, then at least one of X or Y must be N.sup.+ (R.sup.2).sub.2 ;
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Ebetino Frank Hallock
Francis Marion David
Kaas Susan Mary
Clark Karen F.
Hake Richard A.
Owens Amelia
The Procter & Gamble & Company
Winter William J.
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