Quaternary ammonium substituted N-cinnamylpiperidines

Details Quaternary ammonium substituted N-cinnamylpiperidines Quaternary ammonium substituted N-cinnamylpiperidines

1981-03-26

1982-06-22

Demers, Arthur P.

Harness for working animal

424267, 542447, 546243, C07D21146

Patent

active

043363741

ABSTRACT:
2-Hydroxymethyl-3,4,5-trihydroxypiperidines bearing a quaternary ammonium-substituted cinnamyl group on the piperidine nitrogen atom and their acid addition salts are antihyperglycemic agents. A typical example is 1-(4-trimethylammoniumcinnamyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine chloride.

REFERENCES:
patent: 4182767 (1980-01-01), Murai et al.
patent: 4220782 (1980-09-01), Stoltefuss et al.
Matsumura et al., Chem. Abst. 92 (1980) #147138 and 110857.

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