Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-05-31
2005-05-31
Fredman, Jeffrey (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024330, C435S006120
Reexamination Certificate
active
06900300
ABSTRACT:
A multiplex structure, such as a nucleic acid quadruplex, includes: a first strand containing a first sequence of nucleobases; a second strand containing a second sequence of nucleobases, wherein the second strand is associated with the first strand by Watson-Crick bonding; a third strand containing a third sequence of nucleobases; and a fourth strand containing a fourth sequence of nucleobases, wherein the fourth strand is associated with the second strand and the third strand by Watson-Crick bonding. Formation of the multiplex structure is promoted by monovalent cations (e.g., sodium and potassium), divalent cations, multivalent cations, intercalating agents and/or molecules known to bind within the minor grooves of nucleic acids. The multiplex structure and the process of forming it have diagnostic, therapeutic, prophylactic and nanoengineering applications.
REFERENCES:
patent: 5451502 (1995-09-01), George, Jr.
patent: 5451503 (1995-09-01), Hogan et al.
patent: 5874555 (1999-02-01), Dervan et al.
patent: 5888739 (1999-03-01), Pitner et al.
patent: 5912332 (1999-06-01), Agrawal et al.
patent: 5948897 (1999-09-01), Sen et al.
patent: 6017709 (2000-01-01), Hardin et al.
patent: 6255469 (2001-07-01), Seeman et al.
patent: 6287772 (2001-09-01), Stefano et al.
patent: 6312925 (2001-11-01), Meyer, Jr. et al.
patent: 6420115 (2002-07-01), Erikson et al.
patent: 2333359 (1999-07-01), None
patent: 2338301 (1999-12-01), None
patent: WO 97/45539 (1997-12-01), None
patent: WO 97/45539 (1997-12-01), None
patent: WO 00/20633 (2000-04-01), None
patent: WO 00 43543 (2000-07-01), None
McGavin et al. A computer graphics study of multistranded DNA models. J. Mol. Graphics., vol. 7, pp. 218-232, 1989.*
McGavin et al. A computer graphics study of multistranded DNA models. J. Mol. Graphics., vol. 7, pp. 218-232, 1989.*
McGavin et al. A computer graphics study of multistranded DNA models. J. Mol. Graphics., vol. 7, pp. 218-232, 1989.*
Sinden R. DNA structure and function. Academic Press, Inc., pp. 225-227, 1994.*
Sinden R. DNA structure and function. Academic Press, Inc., pp. 225-227, 1994.*
McGavin, “Models of Specifically Paired Like (Homologous) Nucleic Acid Structures,”J. Mol. Biol.(1971) 55, 293-298.
McGavin, “Relationships and Transformations Between Some Nucleic Acid Models,”J. Theor. Biol.(1980) 85, 665-672.
McGavin, “Four Strand Recombination Models,”J. Theor. Biol.(1989) 136, 135-150.
McGavin, “Four-Strand Structure, Kinks and Cruciforms in DNA,”J. Theor. Biol.(1989) 138, 117-128.
McGavin et al., “A Computer Graphics Study of Multistranded DNA Models,” J. Mol Graphics. (1989) 7, 218-232.
Lishanski et al., “Branch migration inhibition in PCR-amplified DNA; homogeneous mutation detection”,Nucleic Acids Research, vol. 28, No. 9, pp. e42i-e42 vii, (May 1, 2000).
Deng et al., “Duplex to quadruplex equilibrium of the self-complementary oligonucleotide”Biopolymer, vol. 35, No. 6, pp. 677-681, (1995).
Salisbury et al., The bi-loop, a new general four-stranded DNA motif,Prol. Natl. Acad. Sci. USA.vol. 94, pp. 5515-5518 (May 1997).
Eckhart, et al.,The Journal of Biological Chemistry,vol. 274, No. 5, pp. 2613-2615, (Jan. 29, 1999).
Rocher, Christophe et al.,Nucleic Acids Research, “Initiation of DNA replication by DNA polymerases from primers forming a triple helix,” 2001, vol. 29, No. 16, 3320-3326.
Sen et al., Nature 334:364-366 (1988).
Williamson et al. Cell 59:871-880 (1989).
Sen et al., Biochemistry 31:65-70 (1992).
Marsh et al., Biochemistry 33:10718-10724 (1994).
Marsh et al., Nucl. Acids Res. 23:696-700 (1995).
Mazumder et al., Biochemistry 35:13762-13771 (1996).
Carlsson et al., Nature 380:207 (1996).
Baran et al., Nucleic Acids Research 25:297-303 (1997).
Floris, et al., “Effect of cations on purine-purine-pyrimidine”, 260 Eur. J. Biochem. 801-809 (1999).
U.S. Appl. No. 09/224,505, Daksis et al.
U.S. Appl. No. 09/468,679, Daksis et al.
U.S. Appl. No. 09/613,263, Erikson et al.
Daksis Jasmine I.
Erikson Glen H.
Caesar Rivise Bernstein Cohen & Pokotilow Ltd.
Chunduru Suryaprabha
Fredman Jeffrey
Ingeneus Corporation
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