Pyrrolyl oxyphenyl ketones

Details Pyrrolyl oxyphenyl ketones Pyrrolyl oxyphenyl ketones

1975-04-14

1976-12-28

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032643, 2603265R, 424274, C07D20732

Patent

active

040001601

ABSTRACT:
4,5-Dihalopyrrol-2-yl oxyphenyl ketones, prepared either by Friedel-Crafts condensation of a 4,5-dihalopyrrole-2-carboxylic acid halide with an appropriate hydroxy or lower-alkoxy-substituted benzene or by condensation of a hydroxy or lower-alkoxy-substituted benzaldehyde with pyrrole in the presence of sodium hydride followed by halogenation, with elemental chlorine or bromine, of the resulting pyrrol-2-yl oxyphenyl ketone, useful as antibacterial and antifungal agents.

REFERENCES:
birchall et al., Tetrahedron Letters, No. 56, pp. 4879-4882 (1970).
Takeda, J. Am. Chem. Soc. vol. 80, pp. 4749-4750 (1958).
Bailey et al., J. Chem. Soc. D, 1969, (21), (Chem. Common), p. 1284 (1969).
Bailey et al., Can. J. Chem. 48, pp. 2257-2259 (1970).

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