Pyrrolopyrazole, potent kinase inhibitors

Details Pyrrolopyrazole, potent kinase inhibitors Pyrrolopyrazole, potent kinase inhibitors

2005-12-28

2011-11-29

Fetterolf, Brandon (Department: 1628)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C514S260100

Reexamination Certificate

active

08067591

ABSTRACT:
Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.

REFERENCES:
patent: 3423414 (1969-01-01), Blatter
patent: 3526633 (1970-09-01), Gadekar et al.
patent: 3947467 (1976-03-01), Verge et al.
patent: 6013500 (2000-01-01), Minden
patent: 7141568 (2006-11-01), Fancelli et al.
patent: 7531531 (2009-05-01), Fancelli et al.
patent: 7541354 (2009-06-01), Fancelli et al.
patent: 2003/0171357 (2003-09-01), Fancelli et al.
patent: 2007/0004705 (2007-01-01), Brasca et al.
patent: 2009/0221632 (2009-09-01), Fancelli et al.
patent: 48003639 (1973-02-01), None
patent: 51063193 (1976-06-01), None
patent: WO02/12242 (2002-02-01), None
patent: WO2004/013144 (2004-02-01), None
patent: WO2004/056827 (2004-07-01), None
Translation of Opposition paper in connection with Ecuador Application No. SP-07-7580, Date considered in Apr. 11, 2008.
Opposition paper in connection with Costa Rican Application No. 9238 (English Translation Provided), Apr. 11, 2008.
Bagrodia, S., et al., “Cdc42 and PAK-Mediated signaling Leads to Jun Kinase and p38 Mitogen-Activated Protein Kinase Activation,”The Journal of Biological Chemistry, 1995, 27995-24998, vol. 270, No. 2.
Brown, J., et al., “Human Ste20 Homologue hPAK1 Links GTPases to the JNK MAP Kinase Pathway,”Current Biology, 1996, 598-605, vol. 6, No. 5.
Daniels, R., et al., “p21-Activated Protein Kinase : A Crucial Component of Morphological Signaling ?in ,”Trends Biochemical Science, 1999, 350-355, vol. 24.
Gnesutta, N., et al., “The serine/Threonine Kinase PAK4Prevents Caspase Activation and Protects Cells From Apoptosis,”The Journal of Biological Chemistry, 2001, 14414-14419, vol. 276, No. 17.
King, A., et al., “The Protein Kinase Pak3 Positively Regulates Raf-1 Activity Through Phosphorylation of Serine 338,”Nature, 1998, 180-183, vol. 396.
Manser, E., et al., “A brain Serine/Threonine Protein Kinase Activated by Cdc42 and Rac1,”Nature, 1994, 40-46, viol. 367.
Qu, J., et al., “Activated PAK4 Regulates Cell Adhesion and Anchorage-Independent Growth,” Molecular and Cellular Biology, 2001, 3523-3533, vol. 21, No. 10.
Roig, J., et al., “p21-Activated Protein Kinase γ-PAK Is Activated by Ionizing Radiation and Other DNA-Damaging Agents,”The Journal of Biological Chemistry, 1999, 31119-31122, vol. 274, No. 44.
Rudel, T., et al., “Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated activation of PAK2,”Science, 1997, 1571-1574, vol. 276.
Schurmann, A., et al., “p21-Activiated Kinase 1 Phosphorylates The Death Agonist Bad and Protects Cells From Apoptosis,”Molecular and Cellular Biology, 2000, 453-461, vol. 20.
Sells, M., et al., “Emerging From the Pak : The p21-Activated Protein Kinase Family,”Trends in Cell Biology, 1997, 162-167, vol. 7.
Sun, H., et al., “Regulation of the Protein Kinase Raf-1 Oncogenic Ras Through Phosphatidylinositol 3-Kinase, Cdc42/Rac and Pak,” Current Biology, 2000, 281-284, vol. 10.
Yablonski, D., et al., “A Nck-Pak1 Signaling Module Is Required for T-Cell Receptor-Mediated Activation of NFAT, But Not of JNK,” EMBO Journal, 1998, 5647-5657, vol. 17, No. 19.

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