Pyrrolo-pyridine derivatives

Details Pyrrolo-pyridine derivatives Pyrrolo-pyridine derivatives

1994-08-26

1996-11-19

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514254, 544121, 544296, 544357, 544362, 544363, A61K 31495, C07D40102, C07D24102, C07D40302

Patent

active

055763197

ABSTRACT:
A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D.sub.4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs.

REFERENCES:
patent: 3362956 (1968-01-01), Archer
patent: 3511841 (1970-05-01), Archer
Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th Edition, pp. 386-387 (1980).
The Merck Index, 9th Edition, 1976, entries 2176 and 4450.
"Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine", Hubert H. M. Van Tol, et al., Nature, vol. 350, Apr. 18, 1991, pp. 610-614.
"Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1", Roger K. Sunahara, et al., Nature, vol. 350, Apr. 18, 1991, pp. 614-619.

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