Pyrrolidine derivatives and their use as chymase inhibitor

Details Pyrrolidine derivatives and their use as chymase inhibitor Pyrrolidine derivatives and their use as chymase inhibitor

2005-02-08

2005-02-08

Lambkin, Deborah C. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S361000, C548S248000, C548S127000

Reexamination Certificate

active

06852744

ABSTRACT:
Novel pyrrolidine derivatives, being useful as chymase inhibitor or intermediate for synthesis of the active compounds, which has the formula (I): wherein R1is cycloalkyl, substituted or unsubstituted phenyl or naphthyl, indanyl, thienyl, furyl, substituted or unsubstituted indolyl, benzofuryl, substituted or unsubstituted benzothienyl, etc.; R2is H, alkyl, phenyl-lower alkyl, cycloalkyl or cycloalkyl-lower alkyl; R3is (i) substituted or unsubstituted monocyclic heterocyclic group, (ii) substituted or unsubstituted benzene- or pyridine-fused heterocyclic group, or (iii) a group (a): R4and R5are independently H or OH, but R4and R5are not simultaneously H, or both form oxo; n is 0, 1, 2 or 3; or a salt thereof.

REFERENCES:
patent: 9325574 (1993-12-01), None
patent: 0052032 (2000-09-01), None
Patent Abstracts of Japan, vol. 1997, no. 09, Sep. 30, 1997 & JP 09 124691 A (Green Cross Corp: The), May 13, 1997, abstract.
Patent Abstracts of Japan, vol. 1998, no. 06, Apr. 30, 1998 & JP 10 053579 (Fujisawa Pharmaceut Co Ltd) Feb. 24, 1998, abstract.

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