Pyrimidine derivatives for the treatment of abnormal cell...

Details Pyrimidine derivatives for the treatment of abnormal cell... Pyrimidine derivatives for the treatment of abnormal cell...

2006-12-05

2006-12-05

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S324000, C514S275000

Reexamination Certificate

active

07145008

ABSTRACT:
The present invention relates to a compound of the formula 1or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof, wherein R1–R4and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

REFERENCES:
patent: 4507146 (1985-03-01), Tobler et al.
patent: 4983608 (1991-01-01), Effland et al.
patent: 5521184 (1996-05-01), Zimmermann
patent: 5753663 (1998-05-01), Flippin et al.
patent: 5863924 (1999-01-01), Berger et al.
patent: 6297258 (2001-10-01), Wissner et al.
patent: 6600037 (2003-07-01), Davis et al.
patent: 2003/0162802 (2003-08-01), Guo et al.
patent: 2003/0171359 (2003-09-01), Dahmann et al.
patent: 2003/0181474 (2003-09-01), Pease et al.
patent: 2004/0220177 (2004-11-01), Kath et al.
patent: 4029650 (1992-03-01), None
patent: 542079 (1997-07-01), None
patent: 553016 (1997-07-01), None
patent: 9310086 (1993-05-01), None
patent: 9324467 (1993-12-01), None
patent: 9712880 (1997-04-01), None
patent: 9719065 (1997-05-01), None
patent: 9805661 (1998-02-01), None
patent: 9809961 (1998-03-01), None
patent: 9837079 (1998-08-01), None
patent: 9909016 (1999-02-01), None
patent: 9941253 (1999-08-01), None
patent: 00012485 (2000-03-01), None
patent: 00018740 (2000-04-01), None
patent: 00039101 (2000-07-01), None
patent: 01021597 (2001-03-01), None
patent: 01060816 (2001-08-01), None
patent: 01068186 (2001-09-01), None
patent: 01072744 (2001-10-01), None
patent: 02008193 (2002-01-01), None
patent: 02012227 (2002-02-01), None
patent: 02012228 (2002-02-01), None
patent: 02016348 (2002-02-01), None
patent: 02016352 (2002-02-01), None
patent: 02020501 (2002-03-01), None
patent: 02059110 (2002-08-01), None
patent: 02096887 (2002-12-01), None
patent: 02096888 (2002-12-01), None
patent: 03018021 (2003-03-01), None
patent: 03020276 (2003-03-01), None
patent: 03030909 (2003-04-01), None
patent: 03032997 (2003-04-01), None
patent: 03063794 (2003-08-01), None
patent: 03066575 (2003-08-01), None
patent: 03078404 (2003-09-01), None
patent: 03095448 (2003-11-01), None
patent: 04046118 (2004-06-01), None
patent: 04056786 (2004-07-01), None
patent: 04056807 (2004-07-01), None
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition,vol. 1, 1004-1010, 1996.
Wolft Manfred E. “Burger's Medicinal Chemistry, 5ed, Part 1”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutices, 3ed.”, Marcel Dekker, New York. 1996, pp. 451 and 596.
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Vippagunta et al., Advanced Drug Delivery Reviews 48: 3-26, 2001.
Mass, R. D., Int. J. Radiation Oncology Bio. Phys.vol. 58(3):932-940, 2004.
Fabbro et al. Pharmacology & therapeutics 93, 79-98, 2002.
Diringer et al., Journal of Medicinal Chemistry, vol. 13, No. 1, pp. 151-152 (1970).
Stover et al., Current Opinion in Drug Discovery and Development, Current Drugs, London, GB, vol. 2, No. 4, pp. 274-285 (1999).
Kath, J. C., Expert Opinion on Therapeutic Patents, vol. 10, No. 6, pp. 803-818 (2000).
Bramson et al., Journal of Medicinal Chemistry, vol. 44(25), pp. 4339-4358 (2001).
Knockaert et al., Biochemical Pharmacology, vol. 64(5-6), pp. 819-825 (2002).
Supuran et al., Expert Opin. Ther. Patents, vol. 14, No. 1, pp. 35-53 (2004).

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