Pyrimidine and purine derivatives and their use in treating tumo

Details Pyrimidine and purine derivatives and their use in treating tumo Pyrimidine and purine derivatives and their use in treating tumo

1995-12-15

1999-07-27

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514274, 536 278, 536 2781, 544262, 544309, 544310, 544313, A61K 3170, A61K 31505, C07H 19167, C07H 19173, C07D47300

Patent

active

059290463

ABSTRACT:
The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hetero atom chosen from O, N, or S, or a substituted derivative thereof; or (ii) phenyl or a substituted derivative thereof,
R.sup.2 is selected from H, C.sub.1 -C.sub.5 alkyl, halogen or NH.sub.2,
R.sup.4 and R.sup.5 which are the same or different are selected from
H, NH.sub.2 or NO.sub.n where n=1 or 2, or R.sup.4 and R.sup.5 together with the pyrimidine ring form a 5-or 6-membered ring structure containing one or more heterocyclic atoms, and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O.sup.6 -alkylguanine-DNA alkyltransferase (ATase) activity.

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