Pyridyl substituted spirodienes for the treatment of inflammatio

Details Pyridyl substituted spirodienes for the treatment of inflammatio Pyridyl substituted spirodienes for the treatment of inflammatio

1996-07-09

1997-09-23

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 15, 546286, 546293, 546294, 546301, 546302, A61K 3144, C07D21300, C07D21357, C07D21362

Patent

active

056705107

ABSTRACT:
A class of substituted spirodienes is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein A is selected from ##STR2## wherein each of R.sup.1 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl; alkoxyalkyl, hydroxyl, mercapto, alkylsulfonyl, haloalkylsulfonyl, and sulfamyl; and wherein n is a number selected from 0, 1, 2 and 3; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
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