Process for the asymmetric synthesis of chiral indoline-2-carbox

Details Process for the asymmetric synthesis of chiral indoline-2-carbox Process for the asymmetric synthesis of chiral indoline-2-carbox

1986-02-14

1987-02-17

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C101447

Patent

active

046440810

ABSTRACT:
Disclosed herein is a process for producing an asymmetric indoline-2-carboxylic acid of the structural Formula: ##STR1## wherein X is hydrogen, bromine, chlorine, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, which comprises:

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Hudson, C. B. and Robertson, A. V., Australian Journal of Chemistry 20, 1935-41 (1967).
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Corey et al., Journal of the American Chemical Society, 2476-2488, at 2480 (1970).
Vincent et al., Tetrahedron Letters, vol. 23, No. 16, pp. 1677-1680 at 1678 (Apr./May 1982).
Hepburn et al., Chem. Abstracts, 82: 3698n (1975).

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