Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-03-25
2008-10-07
Wilson, James O. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07432369
ABSTRACT:
The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction due to surgery, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, or to prolong the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of a Pyridyl-Substituted Porphyrin Compound.
REFERENCES:
patent: 4822899 (1989-04-01), Groves et al.
patent: 5223538 (1993-06-01), Fridovich et al.
patent: 5227405 (1993-07-01), Fridovich et al.
patent: 5650137 (1997-07-01), Nguyen et al.
patent: 5723677 (1998-03-01), Wijesekera et al.
patent: 5994339 (1999-11-01), Crapo et al.
patent: 6002026 (1999-12-01), Groves et al.
patent: 6013241 (2000-01-01), Marchal et al.
patent: 6087493 (2000-07-01), Wheelhouse et al.
patent: 6103714 (2000-08-01), Fridovich et al.
patent: 6127356 (2000-10-01), Crapo et al.
patent: 6194566 (2001-02-01), Platzek et al.
patent: 6204259 (2001-03-01), Riley et al.
patent: 6245758 (2001-06-01), Stern et al.
patent: 6372727 (2002-04-01), Crow et al.
patent: 6403788 (2002-06-01), Meunier et al.
patent: 6448239 (2002-09-01), Groves et al.
patent: 6479477 (2002-11-01), Crapo et al.
patent: 6544975 (2003-04-01), Crapo et al.
patent: 6573258 (2003-06-01), Bommer et al.
patent: 6583132 (2003-06-01), Crapo et al.
patent: 6730666 (2004-05-01), Yayon et al.
patent: 6916799 (2005-07-01), Fridovich et al.
patent: 6969707 (2005-11-01), Groves et al.
patent: 2002/0042407 (2002-04-01), Fridovich et al.
patent: 2003/0055032 (2003-03-01), Groves et al.
patent: 2003/0069281 (2003-04-01), Fridovich et al.
patent: 2003/0086916 (2003-05-01), Goligorsky et al.
patent: 2004/0019031 (2004-01-01), Crapo et al.
patent: 2004/0023941 (2004-02-01), Crapo et al.
patent: 2004/0039211 (2004-02-01), Fridovich et al.
patent: 2004/0058902 (2004-03-01), Batinic-Haberle et al.
patent: 2006/0199792 (2006-09-01), Groves et al.
patent: 2007/0072825 (2007-03-01), Williams
patent: 200054603 (2000-12-01), None
patent: 2 373 336 (2000-12-01), None
patent: 19647640 (1998-05-01), None
patent: 1 185 532 (2000-12-01), None
patent: 03-038587 (1991-02-01), None
patent: WO 95/10185 (1995-04-01), None
patent: WO 96/39409 (1996-12-01), None
patent: WO-99/23097 (1999-05-01), None
patent: WO 99/55388 (1999-11-01), None
patent: WO 00/43395 (2000-07-01), None
patent: WO 00/75144 (2000-12-01), None
patent: WO 02/100994 (2002-12-01), None
patent: WO 03/078436 (2003-09-01), None
patent: WO 2007/064795 (2007-06-01), None
Batinic-Haberle I, Spasojevic I, Stevens RD, Hambright P, Neta P, Okado-Matsumoto A, Fridovich I. New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho methoxyethylimidazolylporphyrins.Dalton Trans.Jun. 7, 2004;(11):1696-702.
Batinic-Haberle I, Spasojevic I, Fridovich I. Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin.Free Radic Biol Med.Aug. 1, 2004;37(3):367-74.
Batinic-Haberle I, Benov L, Spasojevic I, Fridovich I. The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic.J Biol Chem.Sep. 18, 1998;273(38):24521-8.
Batinic-Haberle I, Liochev SI, Spasojevic I, Fridovich I. A potent superoxide dismutase mimic: manganese beta-octabromo-meso-tetrakis-(N-methylpyridinium-4-yl) porphyrin.Arch Biochem Biophys.Jul. 15, 1997;343(2):225-33.
Benov L, Batinic-Haberle I, Spasojevic I, Fridovich I. Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers.Arch Biochem Biophys.Jun. 15, 2002;402(2):159-65.
Benov L, Fridovich I. Superoxide dependence of the toxicity of short chain sugars.J Biol Chem.Oct. 2, 1998;273(40):25741-4.
Benov L, Fridovich I. The rate of adaptive mutagenesis inEscherichia coliis enhanced by oxygen(superoxide).Mutat Res.Oct. 25, 1996;357(1-2):231-6.
Benov L, Fridovich I. A superoxide dismutase mimic protects sodA sodBEscherichia coliagainst aerobic heating and stationary-phase death.Arch Biochem Biophys.Sep. 10, 1995;322(1):291-4.
Bowler RP, Arcaroli J, Abraham E, Patel M, Chang LY, Crapo JD. Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury.Am J Physiol Lung Cell Mol Physiol.Apr. 2003;284(4):L680-7.
Bowler RP, Sheng H, Enghild JJ, Pearlstein RD, Warner DS, Crapo JD. A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.Free Radic Biol Med.Oct. 15, 2002;33(8):1141-52.
Camhi et al., Induction of Heme Oxygenase-1 Gene Expression by Lipopolysaccharide Is Mediated by AP-1 Activation,Am. J. Respir. Cell Mol. Biol..,vol. 13, No. 4, 10 1995, 387-398.
Chang LY, Crapo JD. Inhibition of airway inflammation and hyperreactivity by a catalytic antioxidant.Chest.Mar. 2003;123(3 Suppl):446S.
Chang LY, Subramaniam M, Yoder BA, Day BJ, Ellison MC, Sunday ME, Crapo JD. A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia.Am J Respir Crit Care Med.Jan. 1, 2003;167(1):57-64.
Chang LY, Crapo JD. Inhibition of airway inflammation and hyperreactivity by an antioxidant mimetic.Free Radic Biol Med.Aug. 1, 2002;33(3):379-86.
Chaniotakis NA, Chasser AM, Meyerhoff ME, Groves JT. Influence of porphyrin structure on anion selectivities of manganese(III) porphyrin based membrane electrodes.Anal Chem.Jan. 15, 1988;60(2):185-8.
Cross et al., A Catalyst of Peroxynitrite Decomposition Inhibits Murine Experimental Autoimmune Encephalomyelitis,Journal of Neuroimmunology107 (2000) 21-28.
Crow, Manganese and Iron Porphyrins Catalyze Peroxynitrite Decomposition and Simultaneously Increase Nitration and Oxidant Yield: Implications for Their Use as Peroxynitrite Scavengers in Vivo,Archives of Biochemistry and Biophysics, vol. 371, No. 1, pp. 41-52, 1999.
Cuzzocrea et al., Antioxidant Therapy: A New Pharmacological Approach in Shock, Inflammation, and Ischemia/Reperfusion Injury, Pharm.Rev.,53:135-159 (2001).
Cuzzocrea et al., Beneficial Effects of Peroxynitrite Decomposition Catalyst in a Rat Model of Splanchnic artery Occlusion and Reperfusion,The FASEB Journal, vol. 14, 2000, 1061-1072.
Dal Maso et al., Epidemiology of non-Hodgkin Lymphomas and Other Haemolymphopoietic Neoplasms in People With Aids,Lancet Oncol(2003) 4(2):110-9.
Day BJ, Batinic-Haberle I, Crapo JD. Metalloporphyrins are potent inhibitors of lipid peroxidation.Free Radic Biol Med.Mar. 1999;26(5-6):730-6.
Day BJ, Crapo JD. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced lung injury in vivo.Toxicol Appl Pharmacol.Sep. 1996;140(1):94-100.
Day BJ, Fridovich I, Crapo JD. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury.Arch Biochem Biophys.Nov. 15, 1997;347(2):256-62.
Dirsch et al., Structural Requirements of Sesquiterpene Lactones to Inhibit LPS-Induced Nitric Oxide Synthesis in RAW 264.7 Macrophages,Bioorganic&Medicinal Chemistry8 (2000) 2747-2753.
El-Serag, Hepatocellular Carcinoma,J Clin Gastroenterol(2002) 35(5 Suppl 2):S72-8.
Evgenov et al., Parenteral Administration of Glipizide Sodium Salt, An Inhibitor of Adenosine Triphosphate-Sensitive Potassium Channels, Prolongs Short-Term Survival After Severe Controlled Hemorrhage in Rats,Crit Care Med.,Oct. 2003;31(10):2429-36.
Faulkner KM, Liochev SI, Fridovich I. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo.J. Biol Chem.Sep. 23, 1994;269(38):23471-6.
Ferdinandy et al, Peroxynitrite Is a Major Contributor to Cytokine-Induced Myocardical Contractile Failure,Circulation Research241-247 (2000).
Ferrer-Sueta G, Vitturi D, Batinic-Ha
Southan Garry
Williams William
Inotek Pharmaceuticals Corporation
Lahive & Cockfield LLP
Remillard, Esq. Jane E.
Soroos, Esq. Cynthia M.
Ward Paul V.
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