Pyrido[2,3-c]-acridine-1-hydroxy-2-carboxylic acid derivatives

Details Pyrido[2,3-c]-acridine-1-hydroxy-2-carboxylic acid derivatives Pyrido[2,3-c]-acridine-1-hydroxy-2-carboxylic acid derivatives

1975-06-23

1977-11-29

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424257, C07D47104, A61K 3147

Patent

active

040605272

ABSTRACT:
Novel compound of the following formula ##STR1## wherein X is a member selected from the group consisting of carboxy and carbalkoxy and each or R.sub.1, R.sub.2 and R.sub.3 is a member selected from the group consisting of hydrogen, alkyl, alkenyl, aryl, alkoxy, hydroxy, halo, amino, alkylamino, alkylmercapto, nitro, cyano, alkylsulfonyl, carboxy, carbalkoxy, hydroxyalkyl, aminoalkyl, hydroxyalkylamino, and acetoxyalkylamino, and pharmaceutically acceptable acid addition salts thereof.
The above compound can be prepared by heating a 3-(substituted amino)-acridine to cyclize said compound, and if desired, hydrolyzing the resulting product and/or it with an acid.

REFERENCES:
patent: 2477048 (1949-06-01), Dobson et al.
patent: 3300499 (1967-01-01), Lesher
patent: 3313817 (1967-04-01), Lesher
patent: 3907798 (1975-09-01), Lesher
Dobson et al, Chemical Abstracts, 40 4377.sup.8 (1946).
Kermack et al, Chemical Abstracts, 36 3803.sup.8 (1942).
Dobson et al., Chemical Abstracts 42 4590 (1948).

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