Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-03-27
2008-09-09
Chang, Celia (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S193000
Reexamination Certificate
active
07423050
ABSTRACT:
The present invention relates to compounds of formula I:or pharmaceutically acceptable acid addition salts thereof, where;R1is C1-C6alkyl, substituted C1-C6alkyl, C3-C7cycloalkyl, substituted C3-C7cycloalkyl, C3-C7cycloalkyl-C1-C3alkyl, substituted C3-C7cycloalkyl-C1-C3alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle;R2is hydrogen, C1-C3alkyl, C3-C6cycloalkyl-C1-C3alkyl, or a group of formula IIR3is hydrogen or C1-C3alkyl;R4is hydrogen, halo, or C1-C3alkyl;R5is hydrogen or C1-C3alkyl;R6is hydrogen or C1-C6alkyl; andn is an integer from 1 to 6 inclusively.The compounds of the present invention are useful for activating 5-HT1Freceptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.
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Cohen Michael Philip
Kohlman Daniel Timothy
Liang Sidney Xi
Mancuso Vincent
Victor Frantz
Chang Celia
Eli Lilly and Company
Elrifi Ivor R.
Erlacher Heidi A.
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