Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-12-30
2009-10-13
Seaman, D. Margaret (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S302000, C546S116000, C546S122000
Reexamination Certificate
active
07601736
ABSTRACT:
The invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.
REFERENCES:
Van Allan et al., Journal of Heterocyclic Chemistry (1970), 7(3), 495-507.
Elmaati et al., Journal of the Chinese Chemical Society (Taipei, Taiwan) (2002), 49(6), 1045-1050.
Eugster et al., Helvetica Chimica Acta (1957), 40, 69-79.
Govindachari et al., Journal of the Chemical Society (1957) 551-6.
Birkofer et al., Chemische Berichte (1957), 90, 2933-40.
Trommer et al., Tetrahedron Letters (1973), (17), 1447-8.
Rygg M et al., Scandinavian journal of immunology, (Jun. 2001), vol. 53, No. 6, pp. 588-595.
Kametani, Tetsuji et al. Studies on the Syntheses of Heterocyclic Compounds, 657.1aTotal Synthesis of Angustine, Nauclefine, and Gentianine1b, J. Org. Chem., vol. 41, No. 15, 1976, pp. 2542-2545.
Oehlke, J. et al.: ‘Darstellung einiger 4- und 5-substituierter Pyridin-2-carbonsauren als Fusarsaureanaloga’,Pharmazie, 38 (1983) pp. 591-596.
Dondoni, Alessandro et al.: Model Studies toward the Synthesis of Dihydropyrimidinyl and Pyridyl α-Amino Acids via Three-Component Biginelli and Hantzsch Cyclocondensations,J. Org. Chem., 2003, 68, pp. 6172-6183.
El-Sedawy, Adel I. et al.: “Metabolism of Swertiamarin fromSwertia japonicaby Human Intestinal Bacteria”,Planta Medica55 (1989), pp. 147-150.
Tada, Masaru et al.: ‘Modification of Pyridine-3-carboxamide (Nicotinamide) by Radical Substitution’,J. Heterocyclic Chem., 26, 45 (1989), pp. 45-48.
Popov, S.S. et al.: “In Vitro Transformations of Gentiopicroside and Swertiamarin”,Journal of Natural Products, vol. 51, No. 4, Jul.-Aug. 1988, pp. 765-768.
Itoh, Atsuko et al.: “Biogenetic Conversion of Tetrahydroisoquinoline-Monoterpene Glucosides into Benzopyridoquinolizine Alkaloids ofAlangium lamarckii”, J. Nat. Prod., 1996, 59, pp. 535-538.
Jahangir et al.: “A New Route to the Indolopyridonaphthyridine Ring System: Synthesis ofN-Benzyl-13b, 14-Dihydronauclefine andN-Benzyl-13b, 14-Dihydroangustine”,Tetrahedron, vol. 43, No. 24, 1987, pp. 5761-5768.
Cho Yong-Baik
Jung Jae Yoon
Kim Hyung Ook
Kim Joo Hyon
Kim Nam Ho
Frommer & Lawrence & Haug LLP
Rahmani Niloofar
Santucci Ronald R.
Seaman D. Margaret
SK Chemicals Co. Ltd.
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