Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-06-29
1981-09-01
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
544244, A61K 3152, C07D47318
Patent
active
042871883
ABSTRACT:
9-(2-Hydroxyethoxymethyl) (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharamceutically acceptable salts, pharmaceutical formulations containing the compounds of this invention, and the treatment of viral infections with these formulations are all disclosed. 9-(2-Hydroxyethoxymethyl)guanine and 2-amino-9-(2-hydroxyethoxymethyl) adenine are examples of especially active compounds of this invention. Also preferred because of its high oral absorption is the phosphate and especially the monophosphate of 9-(2-hydroxyethoxymethyl)guanine as well as pharmaceutically acceptable salts thereof.
REFERENCES:
patent: 4199574 (1980-04-01), Schaeffer
Baker et al., J. Pharm. Sci., 54, No. 6, (1965), pp. 845-848.
Leonard et al., Proc. Nat. Acad. Sci., (1970), 67(1), pp. 93-98.
Brown Donald
Burroughs Wellcome Co.
Coughlan, Jr. Paul M.
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