Pseudorabies virus protein

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 792, 435 794, 435975, G01N 33569

Patent

active

053525752

ABSTRACT:
The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.

REFERENCES:
patent: 4514497 (1985-04-01), Kit et al.
patent: 4609548 (1986-09-01), Kit et al.
patent: 4680176 (1987-07-01), Berns et al.
patent: 4703011 (1987-10-01), Kit et al.
patent: 4711850 (1987-12-01), Kit et al.
patent: 4810634 (1989-03-01), Post et al.
patent: 5047237 (1991-09-01), Cochran et al.
Stevely, J. Virol. 16(5):944-950 (Oct. 1975).
Todd et al., "Enzyme-linked immunosorbent assay for detecting antibodies to Aujeszky's disease virus in pigs", Vet. Record, 109:534-537 (Dec. 1981).
D. P. Gustafson, "Pseudorabies," in Diseases of Swine, 5th ed., A. D. Leman et al., 209-23 (1981).
Jones, T. C. and R. D. Hunt, "Pseudorabies (Infectious Bulbar Paralysis, Aujeszky's Disease, Mad Itch) in Veterinary Pathology", 5th Ed., Lea & Febiger, 322-26 (1983).
C. E. Aronson, "Pseudo-Cine.TM.with Havlogen.RTM.," Veterinary Pharmaceuticals & Biologicals 15/90 (1982-1983).
C. E. Aronson, "PR-VAC.RTM.," and PR-VAC.RTM.-Killed, and PR-VAC.RTM./Leptoferm-5, Veterinary Pharmaceuticals & Biologicals 15/98-99 (1982-1983).
Ben-Porat, T. and A. S. Kaplan, "Synthesis of Proteins in Cells Infected with Herpesvirus V. Viral Glycoproteins," Virology 41:265-73 (1970).
Kaplan, A. S. and T. Ben-Porat, "Synthesis of Proteins in Cells Infected with Herpesvirus, VI. Characterization of the Proteins of the Viral Membrane," Proc. of Natn'l Acad. of Sciences 66(3):799-806.
Norid, B. and B. F. Vestergaard, "Immunoelectrophoretic Identification and Purification of Herpes Simplex Virus Antigens Released from Infected Cells in Tissue Culture," Intervirology 11:104-10 (1979).
Khristova, V. et al., "Thymidine Kinase Activity of Virulent and Vaccinal Strains of Aujezsky's Disease Virus," Veterinary Science XXII(3):15-22.
G. Tatarov, "Apathogenic Mutant of the Aujeszky Virus Induced by 5-Iodo-2-Deoxyuridine (IUDR)," Zentralblatt Veterinarmedizin 15:847-53 (1968).
Randall, R. E. et al., "Glycoproteins with Type Common and Type Specific Antigenic Sites Excreated from Cells Infected with Herpes Simplex Virus Types 1 and 2," J. Gen. Virol. 48:297-310 (1980).
Van Zaane, D. et al., "Molecular-Biological Characterization of Marek's Disease Virus," Virology 121:116-32 (1982).
Randall, R. E. and R. W. Honess, "Proteins of Herpesvirus Saimiri: Identification of Two Virus Polypeptides Released into the Culture Medium of Productively Infected Cells," J. Gen. Virol. 51:445-49 (1980).
Gielkens, A. L. J. et al., "Genome Differences Among Field Isolates and Vaccine Strains of Pseudorabies Virus," J. Gen. Virol. 66:69-82 (1985).
Valenzuela, P. et al., "Antigen Engineering in Yeast: Synthesis and Assembly of Hybrid Hepatitis B Surface Antigen-Herpes Simplex 1 gD Particles," Bio/Technology 3:323-26 (1985).
Kieny, M. P. et al., "Expression of Rabies Virus Glycoprotein From a Recombinant Vaccinia Virus," Nature 312:163-66 (1984).
Holland, T. C. et al., "Antigenic Variants of Herpes Simplex Virus Selected with Glycoprotein-Specific Monoclonal Antibodies," J. of Virology 45(2):672-82 (1983).
Post, L. E. and B. Roizman, "A Generalized Technique for Deletion of Specific Genes in Large Genomes: .alpha. Gene 22 of Herpes Simplex Virus 1 is Not Essential for Growth," Cell 25:227-32 (1981).
Todd, D. and J. B. McFerran, "Control of Aujeszky's Disease," The Veterinary Record 117(24):647(1985).
Thomsen, D. R. et al., "Replication and Virulence of Pseudorabies Virus Mutants Lacking Glycoprotein gX," J. of Virology 61(1):229-32 (1987).
Sandri-Goldin, R. M. et al., "Method for Induction of Mutations in Physically Defined Regions of the Herpes Simplex Virus Genome," J. of Virology 38(1):41-49 (1981).
Quint, W. et al., "Construction and Characterization of Deletion Mutanta of Pseudorabies Virus: A New Generation of `Live` Vaccines," J. Gen. Virol. 68:523-34 (1987).
Roizman et al., Science, 229, 1208-14 (Sep. 1985).
Marchioli et al., Am J. Vet. Res., 481(11), 1577-83 (1987).
Davison et al., Chapter 7, pp. 103-124, in Recombinant DNA Research and Viruses, Becker, et al. 1985.
Thomsen et al., J. Virol, 61(1), 229-37 (1987).
Petrovskis et al., J. Virol, 60(3), 1166-9 (1986).
Ben-Porat, T. et al., J. Virol, 57(1), 191-6 (Jan. 1986).
Robbins et al., J. Virol, 59(3) 635-45, (Sep. 1986).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pseudorabies virus protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pseudorabies virus protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pseudorabies virus protein will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-580699

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.