Proteins with IL-6 inhibiting activity

Details Proteins with IL-6 inhibiting activity Proteins with IL-6 inhibiting activity

2002-12-04

2008-08-19

Rao, Manjunath (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S085200, C514S002600, C530S350000, C530S351000

Reexamination Certificate

active

07414024

ABSTRACT:
The subject of the present invention concerns proteins with IL-6 inhibiting activity and thier use, and the use of proteins containing at least the amino acid seqeunce SEQ ID NO. 4 as medicianl product, in paritcular as anti-cancerous agent.

REFERENCES:
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patent: 94 19004 (1994-09-01), None
patent: 95 13393 (1995-05-01), None
patent: 97 10338 (1997-03-01), None
Chung et al., Specific inhibition of Stat3 signal transduction by PIAS3, 1997, Science, vol. 278, pp. 1803-1805.
Alberti et al., IL-6 as an intracrine growth factor for renal carcinoma cell lines, 2004, International Journal of Cancer, vol. 111, pp. 653-661.
Dermer, Another anniversary for the war on cancer, 1994, Biotechnoloy, vol. 12, p. 320.
Jain, Vascular and interstitial barriers to delivery of therapeutic agents in tumors, 1990, Cancer and Metastasis Reviews, vol. 9, p. 253-266.
Zips et al., New anticancer agents: in vitro and in vivo evaluation, 2005, In Vivo, vol. 19, pp. 1-8.
Wlaschek et al, UVA-Induced Autocrine Stimulation of Fibroblast-Derived Collagenase by IL-6: etc., vol. 101, No. 2, 1993, pp. 164-168.
Arcone et al, Internal Deletions of Amino Acids 29-42 of Human Interleukin-6 IL-6, etc., vol. 288, No. 1-2, 1991, pp. 197-200.
Brakenhoff et al, Analysis of Human IL-6 Mutants Expressed inEscherichia coli., vol. 143, No. 4, 1989, pp. 1175-1182.

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