Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1997-06-19
1999-09-14
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530350, A61K 3800, C07K 100
Patent
active
059524634
ABSTRACT:
The present invention relates to a novel proteinase inhibitor useful as a medicine or pesticides and a gene coding for the inhibitor. A proteinase inhibitor (Kexstatin) having inhibitory activity against Kex2 proteinase family enzymes and having a molecular weight of 11,500; a gene coding for Kexstatin; and a method for producing Kexstatin using a microorganism belonging to the genus Streptomyces or transformed with Kexstatin gene are disclosed.
REFERENCES:
patent: 4929553 (1990-05-01), Bussey et al.
patent: 5413914 (1995-05-01), Franzusoff
patent: 5541062 (1996-07-01), Smeekens et al.
patent: 5627043 (1997-05-01), Franzusoff
patent: 5691183 (1997-11-01), Franzusoff et al.
Rudinger (Jun. 1976) Characteristics of the amino acids as components of a peptide hormone sequence. In: Peptide Hormones. Ed. J. A. Parsons. University Park Press, Baltimore, MD. pp. 1-7.
Ngo et al. (Jun. 1994) Computational complexity, protein structure prediction, and the lLevinthal paradox. In The Protein Folding Problem and Tertiary Structure Prediction. Eds. Merz et al. Birkhauser et al. Boston, MA. pp. 491-495.
Thornton et al. (Aug. 1995) Protein Engineering: Editorial Overview. Current Opinion in Biotechnology 6(4): 367-369.
Wallace (Apr. 1993) Understanding cytochrome c function: engineering protein structure by semisynthesis. The FASEB Journal 7: 505-515.
Sugino, H. et al., "Plasminostreptin, a Protein Proteinase Inhibitor Produced by Streptomyces antifibrinolyticus", Journal of Biological Chemistry, vol. 253, Mar. 10, 1978, pp. 1546-1555, XP002086332.
Chaudhuri, B., Stephan, C., "A C-terminal domain, which prevents secretion of the neuroendocrine protein 7b2 in Saccharomyces cerevisiae, inhibits Kex2 yet is processeed by the Yap3 protease" FEBS LETTER., vol. 364, 1995, pp. 91-97, XP002086333.
Seidah, N.G. et al., Mammalian Neural and Endocrine Pro-Protein and Pro-Hormone Convertases Belonging to the Subtilisin Family of Serine Proteases, Enzyme, vol. 45, 1991, pp. 271-284, XP002086334.
Angliker, H., et al., "The Synthesis of Inhibitors For Processing Proteinases and Their Action On the Kex2 Proteinase of Yeast", Biochem. J., vol. 293, 1993, pp. 75-81, XP002086335.
Oda, K., et al., "A Novel Proteinaceous Kex 2 Proteinase Inhibitor, Kexstatin, from Streptomyces Platensis Q268" Biosci. Biotech. Biochem., vol. 60, No. 8, 1996, pp. 1388-1389, XP002086336.
Kikuchi Norihisa
Oda Kohei
Shibano Yuji
Biomolecular Engineering Research Institute
Stole Einar
Wax Robert A.
LandOfFree
Proteinase inhibitor and gene encoding the inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Proteinase inhibitor and gene encoding the inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Proteinase inhibitor and gene encoding the inhibitor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1510865