Proteinaceous substance showing antitumorous action and its prep

Details Proteinaceous substance showing antitumorous action and its prep Proteinaceous substance showing antitumorous action and its prep

1986-07-21

1988-10-11

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530412, 530413, 530415, 530416, 530417, 530825, 435 68, C07K 1500

Patent

active

047772417

ABSTRACT:
A proteinaceous substance having the following biochemical characteristics:

REFERENCES:
patent: 4436656 (1984-03-01), Sasaki et al.
patent: 4481137 (1984-01-01), Ohnishi et al.
Rubin et al., PNAS, 82, 1985, p. 6637.
Zacharchuk et al., PNAS, 80, 1983, p. 6341.
Toth et al., Mol. Immunol. 16, 1979, pp. 671-679.
"Phagocytosis and Cytolysis by a Macrophage Tumour and Its Cloned Cell Line", Nature 257, pp. 393-394 (1975), Ralph et al.
Infection and Immunity, vol. 30, No. 2, 1980, pp. 523-530; D. N. Mannel et al., "Macrophages as a Source of Tumoricidal Activity (Tumor-Necrotizing Factor)" *p. 523, Abstract and right-hand col., paragraph 3*.
Chemical Abstracts, vol. 94, No. 11, Mar. 16th, 1981, p. 257, No. 78873x, Columbus, Ohio, U.S.; N. Matthews et al.: "Tumor-Necrosis Factor from the Rabbit, IV., Purification and Chemical Characterization", & Br. J. Cancer 1980, 42(3), 416-22 *Abstract*.
The Journal of Immunology, vol. 125, No. 4, Oct. 1980, pp. 1671-1677, the Williams & Wilkins Co., U.S.; M. R. Ruff et al.: "Purification and Physicochemical Characterization of Rabbit Tumor Necrosis Factor" *p. 1671, Abstract*.
Proc. Natl. Acad. Sci. U.S.A., vol. 80, Sep. 1983, pp. 5397-5401; B. D. Williamson et al.: "Human Tumor Necrosis Factor Produced by Human B-Cell Lines: Synergistic Cytotoxic Interaction with Human Interferon" *p. 5397, Abstract*.
Chemical Abstracts, vol. 96, No. 9, Mar. 1st, 1982, p. 455, No. 67110m, Columbus, Ohio, U.S.; N. Matthews: "Production of an Antitumor Cytotoxin by Human Monocytes", & Immunology 1981, 44(1), 135-42.

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