Protein hybrid having cytotoxicity and process for the preparati

Details Protein hybrid having cytotoxicity and process for the preparati Protein hybrid having cytotoxicity and process for the preparati

1981-12-16

1983-01-11

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, 424 88, A61K 3944, C07G 700

Patent

active

043681492

ABSTRACT:
A protein hybrid having cytotoxicity obtained by covalently bonding an immunoglobulin or its fragment, which is capable of binding selectively to an antigen possessed by a cell to be destroyed, to a protein, which is obtained from Momordica charantia and has an activity to terminate protein synthesis. This protein hybrid displays remarkable cytotoxicity against targel cells.

REFERENCES:
patent: 4046722 (1977-09-01), Rowland
patent: 4093607 (1978-06-01), Sela et al.
patent: 4315851 (1982-02-01), Yoshikumi et al.
Archives of Biochemistry & Biophysics, 169, 522-528 (1975), Irvin.
J. Natl. Cancer Inst., vol. 61, pp. 657-676, 1978, Ghose et al.
Biochemical Biophysical Res. Commun. vol. 90, pp. 320-360, 1979, Masuho et al.
Biochemical Journal, vol. 186 (Feb. 1980), pp. 443-452, Barbieri et al.

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