Protein having an anti-tumoral effect

Details Protein having an anti-tumoral effect Protein having an anti-tumoral effect

1998-09-22

2001-01-09

Carlson, Karen Cochrane (Department: 1653)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C435S252300, C530S300000, C514S012200

Reexamination Certificate

active

06171818

ABSTRACT:

FIELD OF THE INVENTION
This invention relates to a protein having anti-tumor activity, a DNA encoding the same, a process for the preparing the same and methods for treating malignancies such as cancers with the same.
BACKGROUND OF THE INVENTION
Chemotherapeutic agents are frequently used for treating malignancies including tumors. However, they do not have a selective effect, i.e. they not only attack the tumor to be treated, but they also attack healthy tissue which is in turn considerably damaged. Thus, it is desirable to provide anti-tumor agents for treating tumors selectively. It is an object of the present invention to provide such an agent.
SUMMARY OF THE INVENTION
The present invention relates to a protein having anti-tumor activity. The protein comprises the amino acid sequence of
FIG. 1
or a biologically active analogue thereof having an amino acid sequence differing therefrom by one or several amino acids.
The present invention is based on the finding that a protein present in sea snails or hares, particularly in
Aplysia punctata,
kills tumor cells but not healthy cells. This protein comprises the amino acid sequence illustrated in
FIG. 1
or a biologically active analogue thereof having an amino acid sequence differing therefrom by one or several amino acids.


REFERENCES:
Takamatsu, et al., “Molecular Cloning of the Defense Factor in the Albumen Gland of the Sea HareAplysia Kurodai,”FEBS Letters377:373-376 (1995).
Yamazaki, “Antitumor and Antimicrobial Glycoproteins from Sea Hares,”Comp. Biochem. Physiol.105(C)(2): 141-146 (1993).

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