Protein for inhibiting collagen-stimulated platelet aggregation

Details Protein for inhibiting collagen-stimulated platelet aggregation Protein for inhibiting collagen-stimulated platelet aggregation

1993-04-07

1994-06-28

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530855, 530350, 424550, A61K 3700

Patent

active

053247159

ABSTRACT:
A protein isolated from crude Haementeria officinalis extract which blocks stimulation of platelet aggregation by collagen. The protein has a molecular weight of approximately 16,000. A method of isolating the protein and using the protein to prevent or delay blood coagulation by blocking the stimulation of platelet aggregation by collagen is also described. The protein is useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.

REFERENCES:
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Gasic et al., Cancer Res. 43 pp. 1633-1636 (1983).
Gasic et al., Cancer Res. 44 pp. 5670-5676 (1984).
Tuszynski et al., J. Biol. Chem. 262(20) pp. 9718-9723 (1987).
Han, et al. Gene 75 pp. 47-57 (1989).
Baskova et al. Chem. Abs. 107 No. 23 p. 33 (1987).
Thacker, 69 USPQ 126 (1946).

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