Protein encoded by a nucleic acid

Details Protein encoded by a nucleic acid Protein encoded by a nucleic acid

2004-12-10

2008-05-27

Bunner, Bridget E (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C536S023100, C536S023500

Reexamination Certificate

active

07378498

ABSTRACT:
A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

REFERENCES:
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech 18(1): 34-39, 2000.
Bork, A. Powers and pitfalls in sequence analysis: the 70% hurdle. Genome Res 10: 398-400, 2000.
Doerks et al. Protein annotation: detective work for function prediction. Trends in Genetics 14(6): 248-250, 1998.
Smith et al. The challenges of genome sequence annotation or “The devil is in the details”. Nature Biotech 15: 1222-1223, 1997.
Brenner, S.E. Errors in genome function. Trends in Genetics 15(4): 132-133, 1999.
Bork et al. Go hunting in sequence databases but watch out for the traps. Trends in Genetics. 12(10): 425-427, 1996.
Wells. J.A. Additivity of mutational effects in proteins. Biochemistry 29 (37): 8509-8517, 1990.
Ngo et al. Computational complexity, protein structure prediction, and the Levinthal paradox. The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495, 1994.
Kato et al. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. J Biol Chem 273(37): 23969-23975, 1998.
Tu et al. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21(4):717-26, 1998.
Shin et al. Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J Cell Biol. 162(2):293-303, 2003.
Xiao et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21(4): 707-716, 1998.
Abe et al., “Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction”,J. Biol. Chem., Jul. 5, 1992, vol. 267, No. 9, pp. 13361-13368.
Brakeman et al., “Homer: a protein that selectively binds metabotropic glutamate receptors”,Nature, Mar. 20, 1997, vol. 386, pp. 284-288.
Nagase et al., “Prediction of the coding sequences of unidentified human genes. VII. The complete sequence of 100 new cDNA clones from brain which can code for large proteins in vitro.”DNA Res., 1997, vol. 4, No. 2, pp. 141-150.
Nickels et al., Accesssion No. HSA17829, GenEmbl, direct submission, Jan. 7, 1999.
Ponting et al., “Identification of homer as a homologue of the Wiskott-Aldrich Syndrome protein suggests a receptor-binding function for WH1 domains”,J. Mol. Med., Nov.-Dec. 1997, vol. 75, pp. 769-771.
Roche et al., “Homer 1b Regulates the Trafficking of Group 1 Metabotropic Glutamate Receptors.”J Biol Chem, 1999, vol. 274, No. 36, pp. 25953-25957.
Schoepp et al., “Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors”,TIPS, Dec. 1990, vol. 11, pp. 508-515.
Xiao et al., Accession No. AF093263, direct submission, Nov. 5, 1998.
A Non-final Rejection dated Aug. 1, 2001 (U.S. Appl. No. 09/377,285).
A Notice of Allowance dated Mar. 22, 2002 (U.S. Appl. No. 09/377,285).
A Non-final Rejection dated Nov. 17, 2003 (U.S. Appl. No. 10/192,381).
A Notice of Allowance dated Jun. 3, 2004 (U.S. Appl. No. 10/192,381).

Affiliated with

Also associated with

Rating

Protein encoded by a nucleic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein encoded by a nucleic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein encoded by a nucleic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3982044