Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1985-05-20
1988-01-19
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Lymphokine
424 85, 424 87, 424 88, 424 89, 424 92, 424 93, 514 2, 514 21, 514802, 530364, 530380, 530381, 530382, 530383, 530384, 530386, 530387, 530389, 530390, 530392, 530393, 530397, 530403, 530404, 530405, 530408, 530410, 530806, 530825, 530826, 435177, 435188, A61K 3912, A61K 3902, A61K 3940, A61K 3942, A61K 3700, A61K 3900
Patent
active
047203854
ABSTRACT:
Compositions containing therapeutically or immunologically active proteins are rendered substantially free from infectious agents such as viable viruses and bacteria without substantial loss of therapeutic or immunologic activity by mixing the protein composition with a complex formed from transition metal ions, such as copper ions, and an angularly-fused, polynuclear heterocyclic arene having two nitrogen atoms in a "cis-ortho" relationship, such as phenanthroline, and a reducing agent such as a thiol or ascorbic acid or ascorbate salt or mixtures of ascorbic acid or ascorbate with a thiol in amounts and at a temperature and for a time sufficient to inactivate substantially all of the viruses and bacteria contained therein. Compositions containing therapeutically active proteins substantially free from viral and bacterial infectivity, which have heretofore been unattainable, can be prepared by the method of the invention.
REFERENCES:
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Giblin James A.
Johnson Lester E.
Miles Laboratories Inc.
Schain Howard E.
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