Protein adsorbent and process for the purification of urokinase

Details Protein adsorbent and process for the purification of urokinase Protein adsorbent and process for the purification of urokinase

1979-10-10

1981-03-31

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

536 1, C12N 972

Patent

active

042594480

ABSTRACT:
A novel protein adsorbent having a group of the general formula ##STR1## wherein X is hydrogen, halogen, amino, lower alkyl or lower alkoxycarbonyl as a ligand, is useful for the purification of urokinase by hydrophobic chromatography, particularly for the removal of such kind of pyrogen that is scarcely removed by affinity chromatography on the ordinal adsorbent of urokinase.

REFERENCES:
patent: 3746622 (1973-07-01), Nishikawa et al.
patent: 4066506 (1978-01-01), Johnson et al.
patent: 4165258 (1979-08-01), Pye et al.
Holmberg et al., Biochimica and Biophysica Acta, vol. 445, No. 1, pp. 215-222 (1976).

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