Proteases causing degradation of amyloid .beta.-protein precurso

Details Proteases causing degradation of amyloid .beta.-protein precurso Proteases causing degradation of amyloid .beta.-protein precurso

1993-02-26

1998-12-15

Rollins, John W.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, C12N 950, C12N 948

Patent

active

058495606

ABSTRACT:
A proteolytic factor has been isolated from the brains of humans with Alzheimer's disease which specifically cleaves the peptide having the sequence His-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe (SEQ ID NO: 1) between Met and Asp. This peptide is in the cleavage site of the N-terminal domain of the amyloid .beta.-protein precursor.

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Seubert et al. (1992) Neurobiol. Aging, 3rd Int'l Conf., 13(Suppl), 580, Abst. 317.

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