Prostaglandin analogues

Details Prostaglandin analogues Prostaglandin analogues

1982-06-28

1984-04-17

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

568330, 568379, 536103, 549465, C07C17700, A61K 31215

Patent

active

044434782

ABSTRACT:
Prostaglandin E.sub.1 analogues of general formula: ##STR1## [wherein R.sup.1 represents a bond or a straight- or branched-chain alkylene group containing from 1 to 5 carbon atom(s), and R.sup.2 represents a hydrogen atom, a straight- or branched-chain alkyl group containing from 1 to 8 carbon atom(s), a cycloalkyl group containing from 4 to 7 carbon atoms in the ring and unsubstituted or substituted by at least one stright- or branched-chain alkyl group containing from 1 to 8 carbon atom(s) or a phenyl or phenoxy group unsubstituted or substituted by at least one halogen atoms, trifluoromethyl group or straight- or branched-chain alkyl group containing from 1 to 4 carbon atom(s), with the proviso that, when R.sup.1 represents a bond, R.sup.2 does not represent a phenoxy group,] possess inhibitory activity or gastric ulceration and cytoprotective activity.

REFERENCES:
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patent: 4172839 (1979-10-01), Wissner
patent: 4197245 (1980-04-01), Wissner
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patent: 4212969 (1980-07-01), Wissner
patent: 4215142 (1980-07-01), Hayashi
patent: 4235797 (1980-11-01), Wissner
patent: 4254036 (1981-03-01), Wissner
patent: 4254285 (1981-03-01), Wissner

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