Prostaglandin 12 analogues and their pharmaceutical compositions

Details Prostaglandin 12 analogues and their pharmaceutical compositions Prostaglandin 12 analogues and their pharmaceutical compositions

1978-01-26

1983-08-16

Ford, John M.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

542426, 542429, 549414, 549465, A61K 31557, C07D307935

Patent

active

043991475

ABSTRACT:
Prostaglandin I.sub.2 analogues of the formula: ##STR1## [wherein X represents trans-vinylene or an ethylene group unsubstituted or substituted by a bromine atom at the C-5 position, Y represents trans-vinylene or ethylene, R.sup.1 represents hydrogen or an alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents hydrogen or methyl or ethyl, R.sup.3 represents a single bond or an alkylene group containing from 1 to 4 carbon atoms, R.sup.4 represents hydrogen, an alkyl group containing from 1 to 8 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or a phenyl or phenoxy group unsubstituted or carrying at least one substituent selected from halogen atoms, the trifluoromethyl group and alkyl groups containing from 1 to 3 carbon atoms, and the wavy line attached to the carbon atoms in positions 6, 11 and 15 depicted in the formula represents .alpha.- or .beta.-configuration or mixtures thereof] are new compounds possessing pharmacological properties typical of prostaglandins, for example PGI.sub.2, and are more stable than PGI.sub.2.

REFERENCES:
patent: 3978229 (1976-08-01), Matsumoto et al.
patent: 4045468 (1977-08-01), Kurono et al.
Corey et al., J. Am. Chem. Soc. 99(6), Mar. 16, 1977, 2006-2008.
Pace-Asciak et al., Biochemistry, 10(20), (1971), pp. 3657-3663.

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