Prosaposin and cytokine-derived peptides

Details Prosaposin and cytokine-derived peptides Prosaposin and cytokine-derived peptides

1994-04-21

1997-12-23

Allen, Marianne P.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, C07K 1452

Patent

active

057009090

ABSTRACT:
Prosaposin and peptide derivatives derived therefrom will promote neurite outgrowth in vitro. A peptide consensus sequence was determined by comparing the active neurite outgrowth-inducing saposin C peptide sequence with that of various hematopoietic and neuropoietic cytokines. These cytokine-derived peptides will promote the same processes as their corresponding cytokines. In addition, prosaposin and saposin C promote increased nerve cell myelination ex vivo.

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