Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-10-24
2008-08-12
Solola, Taofiq A (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S281100
Reexamination Certificate
active
07410982
ABSTRACT:
There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4alkyl and C1-C4alkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C1-C4alkyl, and C2-C8alkyl, C2-C8alkenyl, C3-C8cycloalkyl and C4-C8cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4alkyl, C1-C4alkoxy, C1-C4alkyl —S(O)n— where n is 0, 1 or 2, —CF3, —CN and —CONH2; Y is selected from dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, and thienopyridyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C1-C4alkyl, C1-C4alkoxy, C1-C4alkyl-S(O)n— where n is 0, 1 or 2, nitro acetyl, —CF3, —SCF3and cyano; Z is selected from H, OR3or F, wherein R3is selected from H, C1-C6alkyl and phenyl C1C6alkyl; R1and R2are each independently H or C1-C4alkyl; and pharmaceutically acceptable salts thereof.
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King, Med Chem: Principle and Practice (1994), p. 206-208.
David T. Wong et al., LY248686, A New Inhibitor of Serotonin and Norepinephrine Uptake, Neuropsychopharmacology, 1993, 23-33, vol. 8, No. 1.
Boulet Serge Louis
Filla Sandra Ann
Gallagher Peter Thaddeus
Hudziak Kevin John
Johansson Anette Margareta
Anderson Arvie J.
Eli Lilly and Company
Solola Taofiq A
Titus Robert D.
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