Promoting bone formation and inhibiting bone resorption with hig

Details Promoting bone formation and inhibiting bone resorption with hig Promoting bone formation and inhibiting bone resorption with hig

1997-02-20

1998-12-22

Weber, Jon P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 424535, 424568, A01N 3718, A61K 3170, A61K 3520, A61K 3555

Patent

active

058519866

ABSTRACT:
A method for promoting osteoblast proliferation or inhibiting bone resorption comprising administering to a subject in need thereof, a composition comprising High Mobility Group Protein (HMG-1) is disclosed.

REFERENCES:
patent: 5654019 (1997-08-01), Kobayashi et al.
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Merenmies et al., "30-kDa heparin-binding protein of brain (amphoterin) inveolved in neurite outgrowth", J. Biol. Chem. (1991) 266(25): 16722-729.
Shirakawa et al., "Primary Structure of non-histone protein HMG1 revealed by the nucleotide sequence", Biochem. (1988) 27: 6159-63, 1990.
Shakoori et al. "Differential expression of the chromosomal high mobility group proteins 14 and 17 during the onset of diffeentiation in mammalian osteoblasts and promyelocytic leukemia cells", J. Cell. Biochem. (1993) 51: 479-487, 1993.
Wen et al. "A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1", Nucleic Acids Res. (1989) 17(3): 1197-1214, 1989.
Stros et al. "Calcium binding to HMG1 protein induces DNA looping by the HMG-box domains", FEBS Lett. (1994) 344: 201-206, 1994.
Abdul-Razzak et al. "Isolation and characterization of folded fragments released by Staphylcoccal aures proteinase from the non-histone chromosomal protein HMG-1", Biochem. Biophys, Acta (1989) 996: 125-131, 1989.
Tomita et al. "Direct in vivo gene introduction into rat kidney", (1992) 186(1): 129-134, 1992.
Tsuda et al. "Primary structure of non-histone protein HMG1 by the nucleotide sequence", Biochemistry (1988) 27: 6159-6163, 1988.

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