Human tumor-associated Kazal inhibitor-like polypeptides and enc

Details Human tumor-associated Kazal inhibitor-like polypeptides and enc Human tumor-associated Kazal inhibitor-like polypeptides and enc

1997-04-14

1998-12-22

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 691, 4351723, 4352523, 4353201, 536 235, 935 10, 935 14, 530324, 530300, C07K 14435, C12N 1512, C12N 1570, C12N 1579

Patent

active

058519874

ABSTRACT:
The present invention provides a human tumor-associated Kazal inhibitor (HuKI) and polynucleotides which identify and encode HuKI. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of HuKI, as well as diagnostic assays.

REFERENCES:
Horii, A., et al., "Primary Structure of Human Pancreatic Secretory Trypsin Inhibitor (PSTI) Gene," Biochemical and Biophysical Research Communications, 149 (2):635-641 (1987).
Horii, A., et al., "On the cDNA's for Two Types of Rat Pancreatic Secretory Trypsin Inhibitor," Biochemical and Biophysical Research Communications, 162 (1):151-159 (1989) (GI 206468; 206469).
Stenman, U., et al., "Immunochemical Demonstration of an Ovarian Cancer Associated Urinary Peptide," Int. J. Cancer, 30:53-57 (1982).
Huntala, M., et al., "Purification and Characterization of a Tumor-associated Trypsin Inhibitor from the Urine of a Patient with Ovarian Cancer," The Journal of Biological Chemistry, 257 (22):13713-13716 (1982).
Stenman, H., et al., "Biology and function of tumor-associated trypsin inhibitor, TATI," Scand J. Clin Lab Invest, 51 (207):5-9 (1991).
Liepinsh, E., et al., "Solution Structure and Dynamics of PEC-60, a Protein of the Kazal Type Inhibitor Family, Determined by Nuclear Magnetic Resonance Spectroscopy," J. Mol. Biol., 239:137-153 (1994).
Fink, E., et al., "Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to .beta.-subunits of glycoprotein hormones," FEBS, 270 (1,2):222-224 (1990).
Laasik, J., et al., "PEC-60, a Novel Regulatory Peptide Reduces Cyclic AMP Formation in Rat Caudate Nucleus," Biochemical and Biophysical Research Communication, 197 (2):849-852 (1993).
Metsis,M., et al., "Molecular Cloning of PEC-60 and Expression of Its mRNA and Peptide in the Gastrointestinal Tract and Immune System," The Journal of Biological Chemistry, 267 (28):19829-19832 (1992).
Ahren, B., et al., "The Intestinal Peptide PEC-60 Inhibits Insulin Secretion in the Mouse and the Rat," Pancreas, 7 (4):443-446 (1992).
Agerberth, B., et al., "Isolation and characterization of a 60-residue intestinal peptide structurally related to the pancreatic secretory type of trypsin inhibitor: Influence on insulin secretion," Proc. Natl. Acad. Sci. USA., 86:8590-8594 (1989).
Perry, A., et al., "Sequence analysis of monkey acrosin-trypsin inhibitor transcripts and their abundant expression in the epididymis," Biochmica et Biophysica Acta, 1172:159-160 (1993).
Ohmachi, Y., et al., "Expression of the pancreatic secretory trypsin inhibitor gene in the liver infected with hepatitis B virus," Journal of Hepatology, 21:1012-1016 (1994).
Ohmachi, Y., et al., "Overexpression of Pancreatic Secretory Trypsin Inhibitor in Pancreatic Cancer," International Journal of Pancreatology, 15 (1):65-73 (1994).
Halme, L., et al., "Concentration of pancreatic secretory trypsin inhibitor (PSTI), acute phase proteins, and neopterin in Crohn's disease. Comparison with clinical disease activity and endoscopial findings," Scand J. Clin Lab Invest., 53:359-366 (1993).
Medl, M. et al, "TATI (tumour-associated trypsin inhibitor) as a marker of ovarian cancer," Br. J. Cancer, 71:1051-4 (1995).
Pectasides, D., et al., "Squamous Cell Carcinoma Antigen, Tumor-Associated Trypsin Inhibitor, and Carcinoembryonic Antigen for Monitoring Cervical Cancer," Am. J. Clin. Oncol., 17 (4):307-312 (1994).
Horii, A. (GI 206469) GenBank Sequence Database (Accession M27883) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (1989).
Horii, A. (GI 206468) GenBank Sequence Database (Accession M27883) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (1989).
Yamamoto, T. (GI 190688); GenBank Sequence Database (Accession M11949) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (1988).
Yamamoto, T. (GI 190687); GenBank Sequence Database (Accession M11949) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (1988).
Yamamoto, T., et al., "Molecular Cloning and Nucleotide Sequence of Human Pancreatic Secretory Trypsin Inhibitor (PSTI) cDNA," Biochemical and Biophysical Research Communications, 132 (2):605-612 (1985) (GI 190687;190688).

Affiliated with

Also associated with

Rating

Human tumor-associated Kazal inhibitor-like polypeptides and enc does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human tumor-associated Kazal inhibitor-like polypeptides and enc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human tumor-associated Kazal inhibitor-like polypeptides and enc will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2047711