Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-01-04
2005-01-04
McKelvey, Terry (Department: 1636)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
06838556
ABSTRACT:
This invention provides nucleic acid sequences, vectors and host cells comprising regulatory regions associated with various promoters including a cyclin D1 promoter, a CD40L promoter, three HBV promoters (core, pre-S1 and HBV-X), a vancomycin-resistant enterococci (VRE) promoter, an androgen receptor promoter, a Her2 promoter, and β-lactamase promoter. The invention further provides methods of regulating gene expression comprising the regulatory regions of such promoters.
REFERENCES:
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patent: WO 0052179 (2000-09-01), None
patent: WO 0194600 (2001-12-01), None
Hinz, M. et al., “NF-kB Function in Growth Control: Regulation of Cyclin D1 Expression and G0/G1-to-S-Phase Transition,”Mol. Cell. Biol.19:(4) 2690-2698 (1999).
Kitazawa, S. et al., “Transcriptional Regulation of Rat Cyclin D1 Gene by GpG Methylation Status in Promotor Region,”J. Biol. Chem. 274: (40) 28787-28793 (1999).
Laurance, M.E. et al., “Specific down-regulation of an engineered human cyclin D1 promoter by a novel DNA-binding ligand in intact cells,”Nucleic Acids Res.: 29:(3) 652-661 (2001).
Lee, R.J., et al., “pp60v-srcInduction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways,”J. Biol. Chem. 274:(11) 7341-7350 (1999).
Shtutman, M., et al., “The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway,”Proc. Natl. Acad. Sci. USA 96:5522-5527 (1999).
Tetsu, O., et al., “β-Cetenin regulates expression of cyclin D1 in colon carcinoma cells,”Nature, 398:422-426 (1999).
Bruice Thomas W.
Kim Jungsuh P.
Kim Moon Young
Kongpachith Ana
Latour Derek R.
Genelabs Technologies, Inc.
McKelvey Terry
Perkins Coie LLP
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