Products comprising substrates capable of enzymatic cross-linkin

Details Products comprising substrates capable of enzymatic cross-linkin Products comprising substrates capable of enzymatic cross-linkin

1995-03-02

1998-06-30

Patterson, Jr., Charles L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

424 77, 424422, 424484, 424486, 4351723, 514 2, 514 19, 530353, 530356, 530357, 530360, 530402, 530409, C07K 1400, A61K 3800

Patent

active

057735778

ABSTRACT:
Polymers are provided comprising protein polymers comprising blocks of repeating units and sequences comprising amino acids, individually or in defined sequences, capable of enzyme catalyzed covalent bond formation for cross-linking, as exemplified by glutamine and/or lysine reactive for FXIII catalyzed isopeptide formation or non-amino acid polymers having side chains comprising such amino acids or sequences, which may be used for preparation of articles of manufacture, particularly cross-linkable compositions. By appropriate choice of the polymer, resorbable implantable polymers may be used in internal applications for mammals as formed objects or depots.

REFERENCES:
patent: 5049506 (1991-09-01), Stuber
patent: 5243038 (1993-09-01), Ferrari et al.
patent: 5316934 (1994-05-01), Kobayashi et al.
Traore, F. et al. J. Agric. Food Chem. 39:1892-1896 (1991).
Fickenscher, et al., A Photometric Assay for Blood Coagulation Factor XIII (1991) Gosis and Haemostasis 65:535-540.
Kagan et al., "Influence of Sequence and Charge on the Specificity of Lysyl Oxidase toward Protein and Synthetic Peptide Substrates," J. Biological Chemistry (1984) 259: 11203-11207.
Pattanaik et al., "Phophorylation and Dephosphorylation Modulation of an Inverse Temperature Transition," Biochemical and Biophysical Research Communications (1991) 178: 539-545.
Sierra, D. H., "Fibrin Sealant Adhesive Systems: A Review of their Chemistry, Material Properties and Clinical Applications," J. Biomat. App. (1993) 7: 309-352.

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