Production of taxol

Details Production of taxol Production of taxol

1992-03-03

1995-09-19

Geist, Gary

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

549510, C07D30514

Patent

active

054513928

ABSTRACT:
Taxol and radiolabelled taxol are produced from sterilized Yew trees by contacting sterilized Yew tree stock with a reactor solution comprising a reducing agent, an energy source, a buffer to maintain pH in the range of 6.5 to 7.5, a taxol precursor, and a steroid inhibitor. A radiolabelled precursor may be included in the reactor solution to produced radiolabelled taxol.

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M. C. Wani et al, "Journal of the American Chemical Society", vol. 93, May 971, No. 9, pp. 2325-2327.
Chenu et al., J. Labelled Cmpds and Radiopharm., vol. 24, No. 10, "Synthesis of a [.sup.3 H]-Labelled Derivative of the Microtubular Poison Taxol" (1986).
Parness et al., J. Cell. Biol., vol. 91 (Nov. 1981) "Taxol Binds to Polymerized Tubulin In Vitro", pp. 479-487.
Manfredi et al., J. Cell. Biol., vol. 94 (Sep. 1984) "Taxol Binds to Cellular Microtubules", pp. 688-696.

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