Production of lymphoid tissue effector cells reactive against ca

Details Production of lymphoid tissue effector cells reactive against ca Production of lymphoid tissue effector cells reactive against ca

1977-10-21

1988-09-20

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

A61K 3578

Patent

active

047724692

ABSTRACT:
The addition of small amounts of MER to an in vitro culture of animal or human lymphocytes together with cancer cells will greatly potentiate the process by which the lymphocytes become actively cytotoxic to the specific type of cancer cells when injected in vivo. In some cases MER causes sensitization of the lymphocytes even when there is none without the MER. MER cultured in vitro with lymphocytes without specific cancer cells in the culture will cause non-specific cytotoxic sensitization of the lymphocytes. The sensitized cytotoxic reactive cells may be stored cryogenically for use in human cancer therapy.

REFERENCES:
Kedar et al., J. Natl. Cancer Inst. 60: 1097-1106 (1978).
Kedar, J. Immunol. Methods 26: 157-171 (1979).
Kedar et al., J. Immunol. Methods 28: 303-319 (1979).
Kedar et al., J. Immunol. Methods 16: 39-58.
Weiss, Proceedings of the 5th Berkeley Symposium, Berkeley, 1967, pp. 657-706.

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